Paliperidone Induced Hypoglycemia by Increasing Insulin Secretion

Paliperidone Induced Hypoglycemia by Increasing Insulin Secretion

We report the case of a 41-year-old woman with schizophrenia who developed persistent hypoglycemia following paliperidone administration. After discontinuing paliperidone, the hypoglycemia resolved, but symptoms of diabetes emerged. Therefore, it appears that the hypoglycemia induced by paliperidone may mask symptoms of diabetes. Paliperidone may induce hypoglycemia by increasing insulin secret...

Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes.

OBJECTIVE In advanced beta-cell failure, counterregulatory glucagon responses may be impaired due to a reduced decrement in insulin secretion during the development of hypoglycemia. The present studies were therefore undertaken to test the hypothesis that these may be improved by increasing this decrement in insulin secretion. RESEARCH DESIGN AND METHODS Twelve subjects with type 2 diabetes w...

Effect of Naloxon on Counter Insulin Hormone Secretion in Insulin-Induced Hypoglycemia

Increasing early insulin secretion compensate adequately for hepatic insulin resistance in CCl4-induced cirrhosis rats.

A number of recent publications have reported an increased frequency prevalence of glucose intolerance with hyperinsulinemia in liver cirrhosis. The aim of this work was to detect, in CCl(4)-induced liver cirrhosis rat, the presence and starting point of muscle and liver insulin resistance. Eighteen rats received intraperitoneal injection of 2 ml of soybean oil containing of CCl(4) twice a week...

Hypoglycemia Induced by Pregabalin.

7 year o ld female with type-2 diabetes and hypertension of 15 years duration, came with the complaints of burning, tingling, numbness and pin-prickl ing sensation over both the legs and feet for over 3 months. On examination, her BP was 140/90. Neurological examination revealed peripheral neuropathy affecting both the lower limbs. Other systems were normal. Lab data revealed HbA1C 7.2%, creati...